Biosynthesis of the sphingoid bases: a provocation
نویسندگان
چکیده
منابع مشابه
Biosynthesis of the sphingoid bases: a provocation.
Although the investigation of sphingolipid biosynthesis began over 35 years ago, there are still fuzzy spaces in our list of enzymes required for the process. The enzymes that have been uncovered have received only the simplest of characterizations. One goal of this review is to indicate to uncommitted young biochemists who are casting about for a research field-and to mature biochemists-that i...
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Sphingolipid metabolites function as signaling molecules in mammalian cells, influencing cell proliferation, migration, and death. Recently, sphingolipid signaling has been implicated in the regulation of developmental processes in Drosophila melanogaster. However, biochemical analysis of endogenous Drosophila sphingoid bases has not been reported. In this study, a rapid HPLC-based method was d...
متن کاملLong-chain or Sphingoid Bases
Long-chain bases (sphingoids or sphingoid bases) are the characteristic or defining structural unit of the sphingolipids. The bases are long-chain aliphatic amines, containing two or three hydroxyl groups, and often a distinctive trans-double bond in position 4. To be more precise, they are 2-amino-1,3-dihydroxy-alkanes or alkenes with (2S,3R)-erythro stereochemistry, with various further struc...
متن کامل[391 Synthesis of Sphingosine and Sphingoid Bases
Sphingosines are a related class of long chain aliphatic compounds possessing a 2-amino-l,3-diol moiety. The most common member of this group found in nature is ( 2 S , 3 R ) D e r y t h r o 2 a m i n o l , 3 o c t a d e c 4 E e n e diol l a and is frequently referred to as sphingosine. These molecules are the backbone of more complex sphingolipids, including ceramide, sphingomyelin, cerebrosid...
متن کاملSphingoid bases as possible diagnostic parameters.
AIM To determine the concentrations and ratios of sphingoid bases, sphinganine and sphingosine, in the serum and urine of healthy individuals, as a basis for the normal value range, which may be useful in the diagnosis of diseases characterized by sphingolipid metabolism impairment. Possible sex differences were also investigated, as well as effects of hormonal changes on sphingoid base concent...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1984
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)34429-1